Journal: British Journal of Clinical Pharmacology
Article Title: Lack of effect of oral cabotegravir on the pharmacokinetics of a levonorgestrel/ethinyl oestradiol‐containing oral contraceptive in healthy adult women
doi: 10.1111/bcp.13236
Figure Lengend Snippet: Mean plasma concentration‐time profiles for (A) LNG in treatment period 1 (OC alone) and treatment period 2 (OC + CAB) and (B) EO in treatment period 1 (OC alone) and treatment period 2 (OC + CAB). Error bars represent standard deviation. CAB, cabotegravir; EO, ethinyl oestradiol; LNG, levonorgestrel; OC, oral contraceptive
Article Snippet: Plasma samples were analysed for CAB and LNG/EO by Covance Laboratory Inc (Madison, Wisconsin, USA) using a validated analytical method based on protein precipitation, followed by high‐performance liquid chromatography–tandem mass spectrometry analysis for CAB and a validated liquid–liquid extraction with derivatization followed by high‐performance liquid chromatography–tandem mass spectrometry for LNG/EO.
Techniques: Clinical Proteomics, Concentration Assay, Standard Deviation